Yet assessing additive interaction based on replacing risk ratios by odds ratios in formulas that were derived using the former may be erroneous. However, in studies that use odds ratios as the sole measure of effect, the calculation of these measures of additive interaction is usually performed by directly substituting odds ratios for risk ratios. Measures of interaction on the additive scale have been developed using risk ratios. Interaction measured on the additive scale has been argued to be better correlated with biologic interaction than when measured on the multiplicative scale.
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